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SBS 2003 R2 Must Be Installed as The Built-in Administrator
If you try to update SBS 2003 with the new R2 Pack you might get a random error like:

Warning: Exception occured while attempting to get remote target path. This is expected if the Remote.msi file for SBS 2003 is not installed. : System.Exception: Unable to open product {C73E81BF-432C-44E2-831D-F46081CA6E28}, MsiOpenProduct() returned 1605
at Setup_Util.SetupUtil.GetTargetPathOfProduct(String productCode, String target)
at Setup_Util.SetupUtil.FormatBrandingPath(ITextLogger log, String format)

or

Warning: Exception occured while attempting to get client setup target path. This is expected if the Client Setup component for SBS 2003 is not installed. : System.Exception: Unable to open product {7FB55E52-C72D-4165-85D0-383ED3D7253F}, MsiOpenProduct() returned 1605
at Setup_Util.SetupUtil.GetTargetPathOfProduct(String productCode, String target)
at Setup_Util.SetupUtil.FormatBrandingPath(ITextLogger log, String format)

In your log files.

Simply login as the Administrator and run the setup again.

Read more about at the link below.
Source
Damian Leibaschoff
blogs.technet.com/sbs/archive/2006/07/17/442189.aspx

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